This story revolves around Supergirl having her powers taken away from her via some sort of power-sapping pill she was tricked into eating.
The villainess, Starfire, leads a gang of girls who are trying to cause havoc around their city. Supergirl attempts to stop the gang, but gets knocked out in her weakened state. She wakes up tied to a pole, and Starfire knocks her around .
The storyline spans across multiple issues, with Supergirl focused on finding a cure for her powers.