Leo da Vinci ep. 62-63

European 3D animated cartoon about 15-year old Leonardo da Vinci. The female protagonist, Lisa, is kidnapped by some goons. There is a lengthy bondage scene. At one point, Lisa tries to escape but the bad guy pours some sleeping potion in the carriage. He counts down and watches her faint.

https://www.imdb.com/title/tt11521370/