Cassandra Cain and Superboy are drugged and captured by Doctor Sin. The villain try to drown them, but obviously they are able to escape the deathtrap.
Storm receives an invitation to dinner at the Hellfire Club by Shinobi Shaw and a bouquet of roses drugged with a sort of neuro toxin. Despite the drug-induced manipulations, Storm refuse to join the Hellfire Club, so Benedict Kine plays her nervous system, sending her agony. Later Ororo awakes tied to a chair.
In a fight, Mary Jane Watson is knocked out by a thug when he hits her in the head with a gun. Arriving just in time, Spiderman defeats the thug and carries the unconscious damsel to safety.
Source: https://readcomiconline.to/Comic/The-Amazing-Spider-Man-1963/Issue-640?id=4856